Viroporins and inflammasomes: a key to understand virus-induced inflammation
Identifieur interne : 000036 ( Main/Exploration ); précédent : 000035; suivant : 000037Viroporins and inflammasomes: a key to understand virus-induced inflammation
Auteurs : N. S. Farag [Égypte] ; U. Breitinger [Égypte] ; H. G. Breitinger [Égypte] ; M. A. El Azizi [Égypte]Source :
- The International Journal of Biochemistry & Cell Biology [ 1357-2725 ] ; 2020.
Abstract
The article provides a summary on cellular receptors involved in virus immunity. It presents an overview of the current understanding of inflammasomes complex activation, comparing its different types with special focus on NLRP3. The article summarizes key findings on viroporins, a novel class of viral proteins and their role in the virus life cycle and host cell interactions. The article sheds the light on the correlation between viroporins and inflammasomes activation and their possible contribution to aggravated inflammatory cytokines production. The article proposes targeting inflammasomes in combination with viroporin inhibitors in virus-induced disease as an emerging attractive therapeutic option.
Url:
DOI: 10.1016/j.biocel.2020.105738
PubMed: 32156572
PubMed Central: 7102644
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">The article provides a summary on cellular receptors involved in virus immunity.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">It presents an overview of the current understanding of inflammasomes complex activation, comparing its different types with special focus on NLRP3.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">The article summarizes key findings on viroporins, a novel class of viral proteins and their role in the virus life cycle and host cell interactions.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">The article sheds the light on the correlation between viroporins and inflammasomes activation and their possible contribution to aggravated inflammatory cytokines production.</p>
</list-item>
<list-item id="lsti0025"><label>•</label>
<p id="par0025">The article proposes targeting inflammasomes in combination with viroporin inhibitors in virus-induced disease as an emerging attractive therapeutic option.</p>
</list-item>
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<affiliations><list><country><li>Égypte</li>
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